MONDAY, June 16 (HealthDay News) -- A gene therapy that has
extended the lives of dogs with cancer may also be able to help
people who have the disease live longer with a better quality of
life, the therapy's developers say.
The treatment, given only once, was tested successfully on 55
dogs with cancer and anemia. It increases muscle strength and
counteracts common cancer complications such as weakness, weight
loss and anemia, principal investigator Dr. Ruxandra Draghia-Akli,
a researcher with VGX Pharmaceuticals Inc. in The Woodlands, Texas,
said in a prepared statement.
"With our type of gene therapy, we can trick certain types of
cells in the body to naturally produce specific hormones," he said.
These hormones have a muscle-building, or anabolic, effect.
In the study, which was expected to be presented Monday at the
Endocrine Society's annual meeting in San Francisco, 54 percent of
the dogs responded to gene therapy, confirmed by blood tests, after
three months.
Of those dogs, 84 percent lived longer than those that did not
respond to gene therapy and other dogs with cancer that received a
placebo.
The dogs who responded had a better quality of life, especially
a better appetite, and their complications of chemotherapy, such as
vomiting and diarrhea, were greatly reduced, the study found.
VGX Pharmaceuticals has applied to the U.S. Food and Drug
Administration for permission to study this treatment in humans
with cancer cachexia, a form of cancer linked to limited food
intake, Draghia-Akli said.
More information
The American Cancer Society has more about
cancer.
