FRIDAY, May 9 (HealthDay News) -- Clinical practice may be
trumping science when it comes to treatments for prostate
cancer.
According to a new study, many patients are getting a newer,
minimally invasive surgery, because they think it is better than
conventional surgery, even though there is little data on actual
differences in outcomes between the two.
"Patients are choosing and/or being directed towards treatments
without fully understanding how much experience there is with the
treatment in general, how much experience their particular
physician might have doing a particular treatment, and how that
compares to other options out there," said Dr. Ronald D. Ennis,
director of radiation oncology at St. Luke's Roosevelt Hospital,
Continuum Cancer Centers of New York.
The study, appearing in the May 10 issue of the
Journal of Clinical Oncology, found that minimally invasive
radical prostatectomy (MIRP) tended to involve fewer complications
and shorter hospital stays but a higher risk of needing additional
treatment and of experiencing incontinence.
The risks, however, tended to decrease the more experience a
surgeon had under his or her belt.
"This reaffirms what many other manuscripts have shown, if you
go to an individual who has experience, who does this on a
consistent basis, your outcomes will be better," said Dr. Ihor S.
Sawczuk, chief of urologic oncology for the Cancer Center at
Hackensack University Medical Center, in New Jersey. "If you go to
someone who does 20 to 50 procedures a year, that's better than
somebody who only does two to three a year."
Men diagnosed with prostate cancer, the second leading cancer
killer in males, are presented with a maze of treatment
options.
Radical prostatectomy, which is surgery to remove the prostate
and some surrounding tissue, is currently the most common treatment
in the United States. Men can choose between a minimally invasive
procedure (introduced in 2000, which includes both robotic surgery
and conventional laparoscopic surgery) or traditional surgery,
which, these days, still involves only a small incision.
Surprisingly, use of MIRP, still a new procedure, nearly tripled
during the time this study was conducted, from 12.2 percent of
procedures in 2003 to 31.4 percent in 2005. This happened despite
scant evidence on how MIRP compared with more traditional surgery,
the investigators stated.
The reason for this quick adoption, said study author Dr. Jim
Hu, director of minimally invasive urologic oncology at Brigham and
Women's Hospital/Dana-Farber Cancer Institute in Boston, is heavy
direct-to-consumer advertising. "A lot of people are jumping the
gun before any studies are out," he said. "And the studies that are
out are from high-volume, single-center hospitals or academic
institutions rather than what's going on nationwide."
This study involved 2,702 men undergoing one or the other
procedure between 2003 and 2005, all of them Medicare
beneficiaries.
MIRP was associated with fewer perioperative complications than
open radical prostatectomy (29.8 percent versus 36.4 percent,
respectively) and shorter hospital stays (1.4 versus 4.4 days).
This was noteworthy, the authors stated, because a greater
proportion of older men and those with other health problems chose
minimally invasive surgery over open radical prostatectomy. These
men would automatically be at higher risk for complications.
But, 27.8 percent of men undergoing MIRP needed salvage therapy
(hormone therapy or external-beam radiotherapy) within six months
of the surgery, compared with only 9.1 percent of those undergoing
the more traditional surgery.
And this procedure was associated with a higher risk of scar
tissue, which can lead to incontinence and the need for further
surgery.
The study did not look at staging and scoring of the tumor,
meaning that some of the differences seen might be due to
differences in disease rather than in surgical quality, Sawczuk
said.
On the other hand, outcomes between the two procedures were more
equal when MIRP was performed by surgeons with greater experience.
But studies have shown that surgeons may need to perform as many as
150 procedures to duplicate the results of open surgery and as many
as 300 to feel comfortable, Hu said.
"This is relatively new, and patients are all excited about it
and, as a result of increased demand, the suppliers or surgeons
want to rush and give patients what they want, but this is
definitely something where a lot of practice is needed," Hu
said.
More information
Visit the
National Cancer Institute for more on treatment for
prostate cancer.